Although postoperative pelvic radiation and/or chemotherapy are often given, they have not been shown conclusively to increase survival. The most commonly used chemotherapeutic drugs include vincristine + doxorubicin or actinomycin-D + cyclophosphamide + DTIC .
    Advanced leiomyosarcoma is treated with radiation therapy and/or chemotherapy.

Investigational 
• Current studies include comparing postoperative pelvic radiation therapy versus no treatment, and 
  chemotherapy.
• Cisplatin has been shown not to be of benefit.
• For women with advanced disease, doxorubicin in combination with DTIC or cyclophosphamide has been 
  shown to be no more effective than doxorubicin alone.
• Vincristine has been used with actinomycin-D or doxorubicin and cyclophosphamide with or without DTIC 
  with some effectiveness in advanced disease.
• Mitoxantrone , a drug similar to doxorubicin, and ifosfamide are being studied.